Inflammation
Longevity and Age Management
Scientists discover mechanisms of senile blindness
Hyperactive immune resistance has been associated with senile blindness caused by age-dependent macular degeneration (AMD). ... Continue Reading
Revised rheumatoid arthritis guidelines revealed
The treatment of rheumatoid arthritis has significantly improved in recent years with the combinations of medications and the development of new anti-arthritis drugs proving successful in the management of symptoms. ... Continue Reading
New atherosclerosis findings 'could save millions of lives'
Two separate studies by researchers from Harvard and Baylor could lead to new treatments that would reduce heart attacks and strokes considerably. ... Continue Reading
Flavonoids found to 'limit neuroinflammation'
A plant compound present in celery and green peppers has been found to intercept an integral component of the inflammatory response in the brain, providing implications for anti-aging physicians and the treatment of diseases such as Alzheimer's. ... Continue Reading
Molecule That Causes Destructive Lung Inflammation Identified In Cystic Fibrosis Patients
Scientists at Children's Hospital of Pittsburgh of UPMC have identified a protein that is critical to the development of inflammation during lung infection in patients with cystic fibrosis (CF). The identification of this protein, called interleukin-23 (IL-23), is an important finding that gives researchers a specific target for developing new therapies. ... Continue Reading
Study: New way to control inflammation
Immune responses defend against invading pathogens and eliminate dangerous tumor cells, for example, but once the threat has been destroyed, the immune responses must end. If left uncontrolled, immune activity can cause autoimmune conditions in which the immune system attacks healthy tissues of the body. ... Continue Reading
Honey Remedy Could Save Limbs
When Jennifer Eddy first saw an ulcer on the left foot of her patient, an elderly diabetic man, it was pink and quarter-sized. Fourteen months later, drug-resistant bacteria had made it an unrecognizable black mess. Doctors tried everything they knew -- and failed. After five hospitalizations, four surgeries and regimens of antibiotics, the man had lost two toes. Doctors wanted to remove his entire foot. " ... Continue Reading
Brief, High-dose Steroid Treatment Offers Extended Relief To Giant Cell Arteritis Patients
A new study offers both hope and a practical treatment option for patients with giant cell arteritis (GCA). Researchers from Emory University and the Mayo Clinic have found that by treating newly diagnosed GCA patients with just three days of a high-dose intravenous steroid, patients relapsed less in the following year and were able to significantly taper off usage of an oral steroid. The study is published in the October issue of the journal Arthritis & Rheumatism. ... Continue Reading
University of Pennsylvania Researchers Identify Gatekeeper Involved in Chronic Inflammatory Diseases
in Penn Vet's Department of Pathobiology. "Our findings indicate that IL-27 is a prominent factor that helps keep the immune system under control." In previous studies, the researchers found that the IL-27 cytokine limits the duration and intensity of white blood activation, an "off switch" to the cascade of messenger proteins that serve to further activate the immune system. Prior to their research, the general assumption among scientists was that IL-27 promoted inflammation. To understand the role of IL-27 in chronic inflammation, Hunter and his colleagues at the Ludwig Institute in Melbourne, Amgen and the NIH studied mice engineered to lack the receptor that enables IL-27 to function in normal mice. When infected with the parasite Toxoplasma gondii, which causes toxoplasmosis, the mice developed severe brain inflammation that was caused by helper T cells, a type of white blood cell that activates and directs portions of the immune system. Without the ability of IL-27 to regulate the immune system, however, the response to the infection in the brain goes out of control. ... Continue Reading
Aging, Immunodeficiency, Inflammation
Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. ... Continue Reading
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