Eleanor M. Walker, from Henry Ford Hospital (Michigan, USA), and colleagues studied 50 breast cancer patients, randomly assigned to receive either acupuncture or drug (venlafaxine) treatment for 12 weeks. The acupuncture group received treatments twice per week for the first four weeks, and then once a week for the remaining eight weeks, while the drug therapy group took venlafaxine orally each night, 37.5mg the first week and then 75mg for the remaining 11 weeks.  At the end of 12 weeks, all patients stopped their therapy and were followed for one year. Patients kept a diary to record the number and severity of hot flashes, and took surveys to measure their overall health and mental health.   While both groups initially experienced a 50% decline in hot flashes and depressive symptoms, differences began to emerge two weeks post-treatment: The acupuncture group continued to experience minimal hot flashes, while the drug therapy group had a significant increase in hot flashes. The acupuncture group did not experience an increase in the frequency of their hot flashes until three months post-treatment. Noting in addition that ”the acupuncture group experienced no negative adverse effects. Acupuncture had the additional benefit of increased sex drive in some women, and most reported an improvement in their energy, clarity of thought, and sense of well-being,” the researchers conclude that: “Acupuncture appears to be equivalent to drug therapy in these patients. It is a safe, effective and durable treatment for vasomotor symptoms secondary to long-term antiestrogen hormone use in patients with breast cancer.”