Aging Heart Prevented in Elderly Mice

Posted on 2009-10-15 06:00:00 in Longevity | Mechanisms of Aging |

In an effort to reveal the molecular mechanism of cardiac aging, Tetsuo Shioi, from Kyoto University Graduate School of Medicine (Japan), and colleagues suppressed a variant of the P13K (phosphoinositide 3-kinase) gene, which regulates the lifespan of cells and contributes to tissue aging, in a group of elderly mice. By doing so, mice with this suppressed gene exhibited improved cardiac function, less fibrosis (which makes the heart inflexible) and fewer biological markers of aging.  Stating that: “Suppression of phosphoinositide 3-kinase prevented many age-associated changes in the heart and preserved cardiac function of aged mice.” the researchers are hopeful that this evidence may promote innovative approaches to delay or prevent heart failure in humans.

Continue reading…

Yasutaka Inuzuka, Junji Okuda, Tsuneaki Kawashima, Takao Kato, Shinichiro Niizuma, Yodo Tamaki, Yoshitaka Iwanaga, Yuki Yoshida, Rie Kosugi, Kayo Watanabe-Maeda, Yoji Machida, Shingo Tsuji, Hiroyuki Aburatani, Tohru Izumi, Toru Kita, and Tetsuo Shioi. “Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice.”  Circulation, Oct 2009; doi:10.1161/CIRCULATIONAHA.109.871137.


Health Headlines

Gut Bacteria May Promote Weight Gain
In a lab animal model, booming gut flora spawned by the Western diet is linked to obesity.
Reduce Income Inequalities to Save Millions of Lives and Improve Quality of Life
International study reaffirms importance of resolving the income gap between the richest and poorest people in developed countries.
Chocolate May Slash Stress
Switzerland-based research team assesses the metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress hormones.
Among Youngest Older Americans, Disability on the Rise
UCLA researchers find disability rates in Americans entering their 60s are on the rise, potentially fueled by the overweight/obesity epidemic.
Living to 100 Linked to Variant of Telomere Enzyme
Genetic clues to longevity discovered among a homogenous ethnic population.
Keep Muscles Strong to Slash Risk of Cognitive Decline
Rush Alzheimer's Disease Center (USA) researchers find that a loss of muscle strength raises risk of Alzheimer’s Disease and mild cognitive impairment.
Cumulative Exposure to Common Infections May Raise Risk of Stroke
Stroke risk may rise in those with common infectious pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and herpes simplex viruses.
Chemical Present in Plastic Bottles, Canned Products Linked to Male Reproductive Problems
First study in humans links bisphenol A (BPA) exposure to male sexual function problems.
Promote Walking to Encourage Healthy Habits
Simple steps in the community can promote walking among residents.
Poor Leadership at Work Can Make Employees Sick
Study finds that people who are dissatisfied with their workplace bosses not only take more sick leave, but are at increased risk of suffering a heart attack.
Looking for an Anti-aging Doctor?

upcoming Events

U.S. Events
congresses
Las Vegas
fellowships
fellowships
symposium
workshops
  • Advanced Hormone Symposium
    Chicago, IL | Oct. 8-10, 2010

VIDEO: Brain Age Workshop
Dr. Eric Braverman, Director of The Place for Achieving Total Health (PATH Medical), Chairs the Brain Age Workshop taking place Dec. 9, 2009. Held in conjunction with the Winter Session of the 17th Annual World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies. The Brain Age Workshop features presentations on Brain Mind Assessment via Neuropsychological Analysis, Movement Deficiency Syndrome, Hormones and the Brain, Nootropic Drug Mechanisms, and Traumatic Brain Injury. View this video to learn about Dr. Braverman’s brain-based model of aging and age modulation.

International Events
See all events »