Bioengineers Create Stable Networks Of Blood Vessels
Yale biomedical engineers have created an implantable system that can form and stabilize a functional network of fine blood vessels critical for supporting tissues in the body, according to a report in the Proceedings of the National Academy of Sciences.
For body tissue to survive it must receive oxygen delivered through the finest of blood vessels. Led by Erin Lavik, assistant professor of Biomedical Engineering, this study shows that the fine network of blood vessels can be formed. Further, detailed microscopic studies showed that the vascular networks were stable as implants for up to six weeks and were able to connect with larger blood vessel structures.
"This expands our understanding of the neuro-vascular niche and opens up ways to address repair of severed nerves," said Joseph Madri professor of pathology at Yale School of Medicine and a co-author. "We can now study what affects the attraction and repulsion of nerve growth and drug delivery in a model system that can be used in vitro and in vivo."
The researchers used two important engineering enhancements to develop stable functional microcirculation. First, they created a "micro-scaffold" of a macroporous hydrogel polymer. The hydrogel is a three-dimensional, sponge-like material -- highly water-saturable, with a structure of connected pores for cells to grow on and through.
Second, they seeded the hydrogel scaffolds with endothelial cells that make up blood vessel structure along with nerve progenitor cells from the brain. Because there is often an association of nerve connections with vascular networks, they tested to see if a combination of the blood vessel-forming and nerve-forming cells would enhance development of the vascular networks.
"By their nature, hydrogels are well suited for the transport of soluble factors, nutrients or drugs, and waste," said Lavik. "The hydrogel scaffold materials are generally highly biocompatible and safe to implant due to the presence of large volumes of water."
###
The research was funded by grants from the National Institutes of Health, the National Science Foundation and a generous gift from Richard and Gail Siegal. Coauthors on the study were Millicent C. Ford, James P. Bertram, Sara Royce Hynes, Michael Michaud, Qi Li and Steven S. Segal from Yale University and Michael Young from the Scheppens Eye Research Institute in Boston, MA.
Citation: Proc. Natl. Acad. Sciences 103(8): 2512-2517(February 21, 2006). (www.pnas.org_cgi_doi_10.1073_pnas.0506020102)
Health Headlines
upcoming Events
U.S. Events
congresses
fellowships
-
Aesthetic Medicine Module I
Las Vegas, NV | Dec. 9-10, 2009 -
Anti-Aging & Regenerative Medicine Modules I, II, III & IX
Las Vegas, NV | Dec. 10-12, 2009 -
Preventative Medicine, Nutrition & Sports Medicine Module I
Las Vegas, NV | Dec. 9-11, 2009 -
Fellowship in Preventative Medicine, Nutrition & Sports Medicine Module III
Las Vegas, NV | Dec. 11-12, 2009
symposium
-
Advanced Hormone Symposium
Chicago, IL | Oct. 8-10, 2010
VIDEO: Brain Age Workshop
Dr. Eric Braverman, Director of The Place for Achieving Total Health
(PATH Medical), Chairs the
Brain Age Workshop taking place Dec. 9, 2009.
Held in conjunction with the Winter Session of the 17th Annual World
Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies.
The Brain Age Workshop features presentations on Brain Mind Assessment
via Neuropsychological Analysis, Movement Deficiency Syndrome,
Hormones and the Brain, Nootropic Drug Mechanisms, and Traumatic Brain
Injury. View this video to learn about Dr. Braverman’s brain-based
model of aging and age modulation.
International Events
- Mexico City | Jan. 15-17, 2010
- Milan | Mar. 18-20, 2010
- Kuala Lumpur | Apr. 29 - May 2, 2010
- Jakarta | May 2010 (pending)
- Bucharest | May 2010 (pending)
- Seoul | May 2010 (pending)
- Melbourne | Aug. 21-22, 2010
- Dubai | Oct. 26-27, 2010
- Bali | October 2010 (pending)
- Mainz-Frankfurt | Nov. 8-10, 2010
- Sao Paulo | Nov. 12-14, 2010
- Shanghai | November 2010 (pending)





