eMEMBERSHIP  LOGIN

Calorigenic Effects on Growth Hormone:Role of Thyroid Hormone

Posted on April 26, 2003, 2:04 p.m. in (HGH) Clinical Research Abstracts

Calorigenic Effects on Growth Hormone: The Role of Thyroid Hormones

GH administration increases energy expenditure, independent of changes in lean body mass, in healthy, obese, and GH-deficient subjects. This may be casually link to the well known GH-induced increase in peripheral T4 to T3 generation, but experimental data are sparse. In this study we have addressed whether 1) the calorigenic effects of GH administration could be reproduced by oral supplementation of T3 in a dose selected to mimic the GH-induced increase in peripheral T3 levels; and 2) combined GH and T3 administration have a synergistic effect on resting energy expenditure (REE).

Eight normal male subjects (aged 21-27 yr; body mass index, 21.11-27.17 kg/m2 ) were randomly studied during four 10-day treatment periods with 1) daily sc placebo injections and placebo tablets, 2) daily sc GH injections (0.1 IU/kgday) and placebo tablets, 3) daily T3 administration (40 mug on even dates, 20 mug on uneven dates) plus placebo injections, and 4) daily GH injections plus T3 administration. GH administration increased both free T3 (F T3 ) levels [mean SE, 6.2 0.3 (control) vs 7.3 0.5 (GH) pmol/L; P<0.05] and REE (resting energy expenditure) [mean d SE, 1959 67 (control) vs 2164 55 (GH_ Cal/24 h; P<0.01]. T3 administration yielded comparable levels of F T3 (7.7 0.5 pmol/L; T3 vs GH, P=0.37), but did not increase REE (2015 48 Cal/24 h; Tvs control, P=0.23). Combined GH and T3 administration increased REE to a level higher than that seen with T3 alone (2279 68 Cal/24 h; T3 vs GH plus T3 , P3 levels to mimic the expected GH-induced increment in T3 concentrations, as observed in a previous study [5]. The patients were instructed to follow a weight-maintaining diet, including a minimum daily intake of 200 g carbohydrates. At the end of each period, the subjects were hospitalized and kept fasted in the supine position from 2200 h. On the following day, REE was estimated by indirect calorimetry for 30 min.

The Journal of Clinical Endocrinology and Metabolism
T. W., T. G., N.M., J. S. C, J. W., J. O. L. J  April 1, 1996, Vol. 8, No. 4 

  

Health Headlines MORE »

We’ve heard of the power of music; Northwestern Univ. team suggests of “the music of power.”
Consuming a whey protein drink before breakfast may help to manage erratic glucose levels associated with type 2 diabetes.
Absorption of lutein – a key carotenoid for eye health, is enhanced by consuming olive or coconut oil.
Adopt three lifestyle behaviors to help buffer stress-related cellular aging.
In countries with low selenium consumption, lentils may be an affordable and accessible food to supplement the mineral.
Dietary supplementation of fish oil may improve memory function and reduce the incidence of cognitive decline.
Daily supplementation of Vitamin C may help to reduce the incidence of the common cold, in people with low-to-adequate blood levels of the vitamin.
Dietary supplementation of resveratrol may enhance memory performance, among older men and women.
University of California team makes discovery about how we obtain stem cells, with potential applications for creating replacement tissues and organs.
Consumed in the diet, capsaicin – the active ingredient in chili peppers – activates a mechanism that may reduce the risk of colorectal cancer.