Evening Primrose Oil

Evening primrose oil (EPO) is derived from the seeds of the evening primrose plant (Oenothera biennis), native to North America, Europe and parts of Asia. Native Americans used EPO to treat bruises, hemorrhoids, sore throats, and stomach aches. The active ingredient in EPO is gamma linolenic acid (GLA), an omega-6 essential fatty acid that the body converts to the anti-inflammatory prostaglandin E1 (PGE1).

ROLE IN ANTIAGING:

EPO may be considered as an important botanical in combatting the general effects of aging. The body loses its ability to convert dietary fats into GLA with age, thus EPO may be helpful in age-related conditions resulting from GLA deficiency. As such, EPO is often used to relieve the symptoms of rheumatoid arthritis. Some research suggests that EPO may be of benefit to diabetics, as the GLA in EPO has been shown to prevent, and in some cases, reverse nerve damage (neuropathy), which is a common complication of the disease. As GLA helps to keep nerves healthy and combat inflammation, EPO may be helpful in multiple sclerosis. The supplement is also recommended for people suffering from Alzheimer’s-related memory problems, as GLA boosts the transmission of nerve impulses.  Some studies have produced evidence to suggest that EPO may lower cholesterol levels, however other studies have produced conflicting results. EPO is often marketed as a treatment for PMS, however research to support these claims is inconclusive.

Not applicable

The optimal daily intake of EPO is yet to be established. A typical daily dose is 3,000- 6,000 mg, which contains roughly 270-540 mg of GLA. Taking EPO with foods boosts GLA absorption. Some experts recommend taking a supplement containing magnesium, zinc, vitamin C, niacin, and vitamin B6 at the same time as EPO, as the body needs all of these nutrients in order to produce PGE1.

A maximum safe level of EPO has not been established. Nor is there any evidence to confirm the safety of long-term use of EPO, however there have been no reports of any significant toxic side effects associated with EPO.

EPO may worsen symptoms of temporal lobe epilepsy. It should also be avoided by schizophrenics who are prescribed phenothiazine epileptogenic drugs.

VIDEO: Brain Age Workshop
Dr. Eric Braverman, Director of The Place for Achieving Total Health (PATH Medical), Chairs the Brain Age Workshop taking place Dec. 9, 2009. Held in conjunction with the Winter Session of the 17th Annual World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies. The Brain Age Workshop features presentations on Brain Mind Assessment via Neuropsychological Analysis, Movement Deficiency Syndrome, Hormones and the Brain, Nootropic Drug Mechanisms, and Traumatic Brain Injury. View this video to learn about Dr. Braverman’s brain-based model of aging and age modulation.