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Fat May Fuel Cancer

Posted on Nov. 14, 2012, 6 a.m. in Weight and Obesity Cancer
Fat May Fuel Cancer

The World Health Organization reports that in 2008 there were more than 1.4 billion obese adults in the world and that cancer claimed the lives of 7.6 million that year. Whereas a number of previous studies have demonstrated a link between obesity and certain cancer, the physiological causes have not been identified.  Mikhail Kolonin, from, The University of Texas Health Science Center at Houston (Texas, USA), and colleagues completed a study in which adipose stromal cells were transplanted into mice; they observed these cells to become recruited by tumors, where they incorporate into blood vessels and become fat cells.   The researchers also observed that cancer induces a six-fold increase of adipose stromal cell frequency in the systemic circulation – where they are incorporated into blood vessels as pericytes and they can differentiate into adipocytes in an obesity-dependent manner.  The study authors conclude that: “our results suggest that [adipose stromal cells] recruited from endogenous adipose tissue can be recruited by tumors to potentiate the supportive properties of the tumor microenvironment."

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Yan Zhang, Alexes C. Daquinag, Felipe Amaya-Manzanares, Olga Sirin, Chieh Tseng, Mikhail G. Kolonin. “Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment.”  Cancer Res., October 15, 2012.

  

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ANTI-AGING TIP OF THE DAY

Tip #166 - Run Towards A Longer Life
Stanford University School of Medicine (California USA) researchers studied aged 50-plus members of a nationwide running club (matched against healthy controls), many of whom exercised as much as 200 minutes a week at the start of the study. After a 20-year study period, the team found the runners were half as likely to die, as compared to those who did not run. While running was found to reduce the risk not only of heart disease, but of cancer and neurological diseases including Alzheimer’s, the runners also experienced significantly lower disability levels throughout the study period.

Vigorous exercise conducted on a regular basis promotes a healthier – and perhaps longer – lifespan. If running doesn’t appeal to you, try cycling, rollerblading, or other vigorous intensity workout. Prior to starting such an exercise program, consult your physician to assess the level of fitness appropriate to your medical needs.

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