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GI-Digestive Inflammation Metabolic Dysfunction

GI Bacteria Diversity Integral to Health

10 years, 6 months ago

10194  0
Posted on Sep 26, 2013, 6 a.m.

People who do not have a rich array of healthy gut bacteria may be more prone to metabolic dysfunction and low-grade inflammation.

Submitting that:  “We are facing a global metabolic health crisis provoked by an obesity epidemic,” Oluf Pedersen, from the University of Copenhagen (Denmark), and colleagues conducted DNA analysis on intestinal bacteria from 292 Danish patients, 169 of whom were obese and 123 who were not.  The researchers found that among the obese subjects, 23% had low "bacterial richness," with an average of 380,000 microbial genes, compared with an average of 640,000 genes in those who had more diverse microbiomes.  Subjects with less diverse gut bacteria also had greater adiposity, insulin resistance, and dyslipidemia and a more pronounced inflammatory phenotype than those with high bacterial richness.  Those subjects also gained significantly more weight over the previous 9 years.  The study authors submit that these correlations help to “identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.”

Emmanuelle Le Chatelier, Trine Nielsen, Junjie Qin, Edi Prifti, Falk Hildebrand, et al. “Richness of human gut microbiome correlates with metabolic markers.”  Nature 500, 541-546; 28 August 2013.

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