Glucosamine + Chondroitin Benefits Knee Pain

The combination of glucosamine with chondroitin has been shown in a number of previous studies to improve joint pain. Australian researchers involved in the Long-Term Evaluation of Glucosamine Sulfate (LEGS) study report that daily doses of 1500 mg of glucosamine sulfate along with 800 mg of chondroitin sulfate results in a significant decrease of 0.1 mm in joint space narrowing of the knee.  The randomized controlled trial involved 605 men and women, ages 45 to 75 years, who were administered the supplement or placebo, for a two-year study period.  The study authors write that: "Allocation to the glucosamine–chondroitin combination resulted in a statistically significant reduction in [joint space narrowing] at 2 years.”