Goldenseal is native to eastern North America. The dried root and rhizome are used medicinally. With anti-inflammatory and antibiotic properties, the herb goldenseal is effective against bacteria and fungi. Goldenseal can also be made into a paste and applied directly to the skin to treat impetigo, ringworm, and other skin infections.

ROLE FOR ANTI-AGING:

The primary active ingredients in goldenseal are the alkaloids hydrastine and berberine, along with smaller amounts of canadine. Berberine, which has been extensively researched, appears to have a wide spectrum of antimicrobial activity against pathogens, including Chlamydia, E. coli, and Salmonella typhi, as well as viruses and protozoans. The herb also  appears to stimulate the activity of macrophages, the immune cells that attack harmful bacteria.

THERAPEUTIC DAILY AMOUNT:

Standardized extracts supplying 8-12% alkaloids are available; the recommended dose is 250-500 mg three times per day. Goldenseal should not be used continuously for more than 3  weeks, with a break of at least 2 weeks between use.

MAXIMUM SAFE LEVEL: Not established

Taken as recommended, goldenseal is generally regarded as safe, however the herb should be avoided during pregnancy and lactation and by those with heart disease, high blood pressure, and diabetes. Some studies have suggested that Goldenseal may reduce the efficacy of doxycycline and tetracycline. Goldenseal may be contraindicated if allergic to ragweed.