IGF-1 receptor regulates lifespan and resistance to oxidative...
Posted on 2003-04-26 14:15:42 in
(HGH) Clinical Research Abstracts |
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode components of the insulin or insulin-like signalling pathways. Examples include the related tyrosine kinase receptors InR (Drosophila melanogaster) and DAF-2 (Caenorhabditis elegans) that are homologues of the mammalian insulin-like growth factor type 1 receptor (IGF-1R). To investigate whether IGF-1R also controls longevity in mammals, we inactivated the IGF-1R gene in mice (Igf1r). Here, using heterozygous knockout mice because null mutants are not viable, we report that Igf1r( /-) mice live on average 26% longer than their wild-type littermates (P < 0.02). Female Igf1r( /-) mice live 33% longer than wild-type females (P < 0.001), whereas the equivalent male mice show an increase in lifespan of 16%, which is not statistically significant. Long-lived Igf1r( /-) mice do not develop dwarfism, their energy metabolism is normal, and their nutrient uptake, physical activity, fertility and reproduction are unaffected. The Igf1r( /-) mice display greater resistance to oxidative stress, a known determinant of ageing. These results indicate that the IGF-1 receptor may be a central regulator of mammalian lifespan.Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y.
Nature 2003 Jan 9;421(6919):182-7
Institut National de la Sante et de la Recherche Medicale U515, Hopital Saint-Antoine, 75571 Paris 12, France. holzenberger@st-antoine.inserm.fr
PMID: 12483226 [PubMed - indexed for MEDLINE]
Health Headlines MORE »
For every 10 g per day increase in soluble fiber intake, a woman may reduce her risk of breast cancer by up to 26%.
Peptides from soybeans modulate neurotransmitters, thereby helping to boost circulation in the brain.
Capsaicin (found in hot peppers) and capsiates (present in sweet peppers) exert modest weight management benefits.
While over 20% of U.S. adults receive periodic health examinations each year, many do not receive recommended preventive screening tests and counseling services
Researchers from Norway suggest a mechanism by which stress may make a person fat, and being obese may create stress.
Swedish researchers report that people who are short on sleep experience greater levels of hunger.
Among women with Generalized Anxiety Disorder (GAD), regular physical activity helps to reduce anxiety, irritability, feelings of tension, low energy and pain.
For every 100 mg per-day increase in magnesium in the diet, stroke risk may decline by up to 9%.
The best male marathon runners over age 65, and the best female marathon runners over age 45, continue to consistently improve their performance.
UCLA-led team safely uses human embryonic stem cells to treat macular degeneration.
ANTI-AGING TIP OF THE DAY
In Working Order
Men and women who stay mentally engaged in their original occupational field fare after retirement fare best mentally. University of Maryland (Maryland, USA) researchers studied 12,189 retired men and women, ages 51 to 61 years at the beginning of the study. The team revealed that those retirees who continued to work in a bridge job experienced fewer major diseases...
»
MORE
