Marijuana's Active Ingredient May Slow Progression Of Alzheimer's Disease

Posted on 2006-10-18 12:43:05 in Medical Marijuana |

Scientists are reporting discovery in laboratory experiments of a previously unknown molecular mechanism in which the active ingredient in marijuana may slow the progression of Alzheimer's disease (AD).

Scripps Research Institute's Kim D. Janda and colleagues used laboratory experiments to show that delta-9-tetrahydrocannabinol (THC) preserves brain levels of the key neurotransmitter acetylcholine.

Existing medications for AD, including donepezil and tacrine, also relieve AD symptoms by inhibiting the enzyme, acetylcholinesterase, which breaks down acetylcholine.

THC does so by inhibiting an alternative site on acetylchlolinesterase and at lower concentrations, Janda's group reports in an article in the current (Oct. 2) issue of the ACS bimonthly journal, Molecular Pharmaceutics. Their experiments show that THC also prevents formation of the amyloid plaques that are a hallmark of AD and its damage to the brain.

"Our results provide a mechanism whereby the THC molecule can directly impact Alzheimer's disease pathology," they state. They also note that THC may provide a "drug lead" -- a model for developing new and more effective medications with more targeted effects on AD.

The researchers explain that such compounds "may provide an improved therapeutic for Alzheimer's disease, augmenting acetylcholine levels by preventing neurotransmitter degradation and reeducating amyloid beta aggregation, thereby simultaneously treating both the symptoms and progression of Alzheimer's disease."

Read Full Story


Health Headlines

Gut Bacteria May Promote Weight Gain
In a lab animal model, booming gut flora spawned by the Western diet is linked to obesity.
Reduce Income Inequalities to Save Millions of Lives and Improve Quality of Life
International study reaffirms importance of resolving the income gap between the richest and poorest people in developed countries.
Chocolate May Slash Stress
Switzerland-based research team assesses the metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress hormones.
Among Youngest Older Americans, Disability on the Rise
UCLA researchers find disability rates in Americans entering their 60s are on the rise, potentially fueled by the overweight/obesity epidemic.
Living to 100 Linked to Variant of Telomere Enzyme
Genetic clues to longevity discovered among a homogenous ethnic population.
Keep Muscles Strong to Slash Risk of Cognitive Decline
Rush Alzheimer's Disease Center (USA) researchers find that a loss of muscle strength raises risk of Alzheimer’s Disease and mild cognitive impairment.
Cumulative Exposure to Common Infections May Raise Risk of Stroke
Stroke risk may rise in those with common infectious pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and herpes simplex viruses.
Chemical Present in Plastic Bottles, Canned Products Linked to Male Reproductive Problems
First study in humans links bisphenol A (BPA) exposure to male sexual function problems.
Promote Walking to Encourage Healthy Habits
Simple steps in the community can promote walking among residents.
Poor Leadership at Work Can Make Employees Sick
Study finds that people who are dissatisfied with their workplace bosses not only take more sick leave, but are at increased risk of suffering a heart attack.
Looking for an Anti-aging Doctor?

upcoming Events

U.S. Events
congresses
Las Vegas
fellowships
fellowships
symposium
workshops
  • Advanced Hormone Symposium
    Chicago, IL | Oct. 8-10, 2010

VIDEO: Brain Age Workshop
Dr. Eric Braverman, Director of The Place for Achieving Total Health (PATH Medical), Chairs the Brain Age Workshop taking place Dec. 9, 2009. Held in conjunction with the Winter Session of the 17th Annual World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies. The Brain Age Workshop features presentations on Brain Mind Assessment via Neuropsychological Analysis, Movement Deficiency Syndrome, Hormones and the Brain, Nootropic Drug Mechanisms, and Traumatic Brain Injury. View this video to learn about Dr. Braverman’s brain-based model of aging and age modulation.

International Events
See all events »