Promising trial data published for new menopause drug

Posted on 2008-09-29 07:54:09 in Estrogen | Women's Health |

Pharmaceutical company Wyeth has released the results of a study of its new tissue selective estrogen complex (TECS), menopause drug Aprela, a combination of conjugated estrogens and bazedoxifine, an experimental selective estrogen receptor modulator (SERM), designed to prevent and treat postmenopausal osteoporosis.

Results of the study of 3,400 women showed that the drug reduced hot flashes and improved sleep problems, but did not increase breast tenderness. The fact that the drug does not increase breast tenderness is important because increased breast tenderness is one of the main reasons why women choose to stop taking hormone replacement therapy (HRT).

Other studies on Aprela have shown that the drug improves bone mineral density, and, at high doses, reduces excess growth of the endometrium, which can cause breakthrough bleeding and may cause cancer.

News release: Retrospective Analysis of Phase 3 Data Suggest Wyeth's Investigational Compound Bazedoxifene / Conjugated Estrogens Comparable to Placebo on Incidence of Abnormal Mammograms. Wyeth website. September 25th 2008.

 

Health Headlines MORE »

Pepper Compounds for Weight Management
Capsaicin (found in hot peppers) and capsiates (present in sweet peppers) exert modest weight management benefits.
Americans Lag in Preventive Screenings
While over 20% of U.S. adults receive periodic health examinations each year, many do not receive recommended preventive screening tests and counseling services
The Stress – Obesity Connection
Researchers from Norway suggest a mechanism by which stress may make a person fat, and being obese may create stress.
Lack of Sleep Triggers Hunger
Swedish researchers report that people who are short on sleep experience greater levels of hunger.
Knock Out Anxiety
Among women with Generalized Anxiety Disorder (GAD), regular physical activity helps to reduce anxiety, irritability, feelings of tension, low energy and pain.
Magnesium Helps to Reduce Stroke Risk
For every 100 mg per-day increase in magnesium in the diet, stroke risk may decline by up to 9%.
Senior Runners Continue to Excel
The best male marathon runners over age 65, and the best female marathon runners over age 45, continue to consistently improve their performance.
Stem Cell Therapy Restores Vision
UCLA-led team safely uses human embryonic stem cells to treat macular degeneration.
Beware the Office Air
First-of-its-kind study reports that indoor air in offices is an important source of worker exposure to potentially toxic substances.
One in Five US Adults Afflicted with Mental Illness
Twenty percent of Americans ages 18+ experienced a diagnosable mental, behavioral, or emotional disorder in 2010.
Anti-Aging Forum Anti-Aging Forum Anti-Aging Forum Anti-Aging Forum
Anti-Aging textbook Anti-Aging Forum MLDP Anti-aging jobs Join A4M
ANTI-AGING TIP OF THE DAY
A Bright Future
University of Southern Denmark researchers report that more than half of the babies born today in developed countries will live to be 100, and the extended lifespan will likely come with fewer disabilities and limitations. Writing that: “If the pace of increase in life expectancy in developed countries over the past two centuries continues through the 21st century...
» MORE