Resveratrol Identified as an Anti-Cancer Compound
Posted on 2005-04-20 15:58:27 in
Cancer |
(HealthNewsDigest.com).. New research suggests the importance of foods like cranberries that naturally contain resveratrol, an anti-cancer compound. A research team led by Dr. Bharat Aggarwal at the University of Texas M.D. Anderson Cancer Center, in conjunction with Dr. Navindra Seeram of the UCLA Center for Human Nutrition, David Geffen School of Medicine, published their review article, citing more than 70 previous studies, in the journal Anticancer Research.
Antiproliferation
The authors reviewed studies examining resveratrol's ability to suppress proliferation of a wide variety of tumor cells, including lymphoid and myeloid cancers; cancers of the breast, colon, pancreas, stomach, prostate, head and neck, ovary, liver, lung and cervical cancers; melanoma; and muscles. Some studies indicate antiproliferative effects at certain dose ranges but not others, indicating further need for systemic research to test a range of resveratrol concentrations in vitro and then apply those doses in vivo to the different types of tumors.
Apoptosis
Besides inhibiting proliferation, resveratrol was also shown to induce apoptosis through one of two pathways (inducing Fas-dependent apoptosis in some cell lines, and Fas-independent apoptosis in others) in b-cell and t-cell lymphomas; myeloid leukemia; breast, colon, pancreas, stomach, prostate, thyroid and head and neck, ovary, liver, lung, and cervical cancers; and melanoma. Most studies indicate resveratrol does not induce apoptosis in normal cells.
In vitro and animal studies comprised the majority of the research reviewed, though several of the leukemia studies were in vivo. The research points to anti-inflammatory and antioxidant effects of resveratrol as well. Good sources of resveratrol include grapes, peanuts, cranberries and other berries.
The researchers conclude that resveratrol holds great potential in cancer prevention and therapy. In vivo studies clearly showed that resveratrol is pharmacologically safe. Its ability to radiosensitive and chemosensitize suggest additional opportunities. With a simple structure and the presence of hydroxyl groups, resveratrol would also be well suited for structure-activity relationship studies to improve biopotency and bioavailability.
Reference: Aggarwal, BB. Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies. Anticancer Research 2004;24:2783-2840.
Antiproliferation
The authors reviewed studies examining resveratrol's ability to suppress proliferation of a wide variety of tumor cells, including lymphoid and myeloid cancers; cancers of the breast, colon, pancreas, stomach, prostate, head and neck, ovary, liver, lung and cervical cancers; melanoma; and muscles. Some studies indicate antiproliferative effects at certain dose ranges but not others, indicating further need for systemic research to test a range of resveratrol concentrations in vitro and then apply those doses in vivo to the different types of tumors.
Apoptosis
Besides inhibiting proliferation, resveratrol was also shown to induce apoptosis through one of two pathways (inducing Fas-dependent apoptosis in some cell lines, and Fas-independent apoptosis in others) in b-cell and t-cell lymphomas; myeloid leukemia; breast, colon, pancreas, stomach, prostate, thyroid and head and neck, ovary, liver, lung, and cervical cancers; and melanoma. Most studies indicate resveratrol does not induce apoptosis in normal cells.
In vitro and animal studies comprised the majority of the research reviewed, though several of the leukemia studies were in vivo. The research points to anti-inflammatory and antioxidant effects of resveratrol as well. Good sources of resveratrol include grapes, peanuts, cranberries and other berries.
The researchers conclude that resveratrol holds great potential in cancer prevention and therapy. In vivo studies clearly showed that resveratrol is pharmacologically safe. Its ability to radiosensitive and chemosensitize suggest additional opportunities. With a simple structure and the presence of hydroxyl groups, resveratrol would also be well suited for structure-activity relationship studies to improve biopotency and bioavailability.
Reference: Aggarwal, BB. Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies. Anticancer Research 2004;24:2783-2840.
Health Headlines MORE »
For every 10 g per day increase in soluble fiber intake, a woman may reduce her risk of breast cancer by up to 26%.
Peptides from soybeans modulate neurotransmitters, thereby helping to boost circulation in the brain.
Capsaicin (found in hot peppers) and capsiates (present in sweet peppers) exert modest weight management benefits.
While over 20% of U.S. adults receive periodic health examinations each year, many do not receive recommended preventive screening tests and counseling services
Researchers from Norway suggest a mechanism by which stress may make a person fat, and being obese may create stress.
Swedish researchers report that people who are short on sleep experience greater levels of hunger.
Among women with Generalized Anxiety Disorder (GAD), regular physical activity helps to reduce anxiety, irritability, feelings of tension, low energy and pain.
For every 100 mg per-day increase in magnesium in the diet, stroke risk may decline by up to 9%.
The best male marathon runners over age 65, and the best female marathon runners over age 45, continue to consistently improve their performance.
UCLA-led team safely uses human embryonic stem cells to treat macular degeneration.
ANTI-AGING TIP OF THE DAY
In Working Order
Men and women who stay mentally engaged in their original occupational field fare after retirement fare best mentally. University of Maryland (Maryland, USA) researchers studied 12,189 retired men and women, ages 51 to 61 years at the beginning of the study. The team revealed that those retirees who continued to work in a bridge job experienced fewer major diseases...
»
MORE
