Studies of living brain tissue may lead to the development of new stroke therapies
Posted on Jan. 22, 2009, 8:12 a.m. in
Longevity and Age Management |
Stroke |
Dr. Sergei Kirov, a neuroscientist at the Medical College of Georgia Schools of Medicine and Graduate Studies, is using slices of living human brain tissue to identify potential new therapies for stroke patients. As he notes, a stroke “takes away” the pump that maintains necessary levels of sodium and potassium in and around brain cells. When the pump is not working accurately, cells become bloated and die. Resulting “waves” cause much of the immediate brain cell death in the stroke's core, with milder waves continuing in contiguous areas called the penumbra. This can potentially increase stroke size and damage. Using an animal model, Dr. Kirov is looking at several drugs to evaluate whether the pounding of the penumbra can be stopped. He has also completed a small pilot study using live human tissue.
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