« Back to Speakers List
Alan Cash, MD
Alan Cash, MD
Abstract

The human metabolite oxaloacetate is central to metabolism.  Our tests indicate that supplementation with oxaloacetate increases lifespan by 25% (p<0.001) in a variety of short-lived species.  The longevity is due to the stimulation of molecular and genomic pathways also stimulated by calorie restriction, starting with an increase in the NAD+/NADH ratio and requiring AMPK activity.

Prior to our work showing oxaloacetate to be a calorie restriction mimetic, oxaloacetic acid has been implicated in various life-extending molecular pathways, including mitochondrial DNA protection, reduction in fasting glucose levels, neural anti-oxidant protection, protection of cells in the retina, pancreas and prevention of the spread of some types of cancer.

Since oxaloacetate is a human metabolite with high bioavailability, low toxicity and high tolerance levels, our results suggest that it may provide a feasible means to access the health benefits of calorie restriction without the requirement of reducing caloric intake.

Goals

1. Oxaloacetate provides for DNA and cellular protection in many tissues.
2. Oxaloacetate supplementation increases lifespan and normalizes glucose metabolism.
3. Oxaloacetate is an unstable molecule and only stabilized product should be used at room temperatures.
4. Oxaloacetate down regulates the molecular pathways that create and store fat.

Bio

Alan Cash is a physicist focused on the metabolic energy pathways of calorie restriction and methods to reproduce the effects of calorie restriction with small molecules rather than extreme diets.  Collaborations include the US National Institute of Aging’s “Interventions Testing Program” which investigates treatments with the potential to extend lifespan and delay disease.

Tell me about Attending Tell me more about exhibiting
 
Find an Anti-aging Doctor!

  
View Current Anti-Aging Newsletter!
Second Opinion with Dr. Ron Klatz
Solutions to improve your life, and your lifespan too.
radio tower Dr. Ronald Klatz, A4M physician founder, interviews the world’s top anti-aging experts in health, longevity, brain fitness, aesthetic beauty, and more. Get the answers to look and feel twenty years younger today.
Tune in to Second Opinion with Dr. Ronald Klatz. »

upcoming Events

U.S. Events
symposiums
workshops
congresses
Las Vegas
fellowships
fellowships
International Events
See all events »