The Powerful Placebo Helping the Brain Heal the Body

Historically, placebos have been a key part of testing if a new treatment works. In some types of clinical trials, participants are given either an active treatment or a placebo. But they aren’t told which one they’re getting. The treatment must do more to improve the participants’ condition than the placebo. If both groups show similar improvement, it may be from the placebo effect, not the drug.

The placebo effect works by turning on the body’s natural mechanisms for helping us feel better. Our brains make many substances that can lessen pain, stress, anxiety, and other unpleasant feelings.

Dr. Luana Colloca, a physician-scientist at the University of Maryland, Baltimore, calls this our “inner pharmacy.” Just expecting to feel better can cause the release of these substances.

“Our mindset is so critical,” Colloca says, “because our thoughts are not independent from our bodies’ responses.”

The placebo effect can be powerful. It can help with pain, fatigue, depression, anxiety, or nausea. But our inner pharmacy can’t treat everything. It can’t, for instance, make tumors go away, lower your cholesterol, or get rid of infections.

NIH-funded researchers are trying to understand the brain pathways underlying the placebo effect. They’re also looking for ways to use it to improve treatments.

Recent studies have been exploring if placebos can be used to cut down on how much medication people take. People with a chronic disease may need to take a drug for a long time. Researchers are testing if placebos can be used to replace some drug doses. These are called dose-extending placebos. The drug effects might continue working for some time as if the patient had taken a real dose.

Dose-extending placebos may be particularly useful with opioids. Opioids are sometimes used to treat chronic pain. But they can be highly addictive and may pose risk for overdose or even death. Scientists are studying whether dose-extending placebos can reduce the chances of opioid addiction.

But for a placebo to work, do you need to believe you’re taking the real thing? Recent research suggests that may not be the case. That’s because your expectations can also affect how well a treatment works.

For instance, if you’re given a drug for pain, it may work better if you’re told that it’s a potent pain treatment. This approach can work for placebos, too—if you’re truthfully told that it has been shown to help.

A drug may also be more effective if you’ve had a good experience with it before. Colloca’s research has shown that even seeing someone else get relief from a treatment can make it more effective.

For these reasons, good communication between patients and healthcare providers is an essential part of treatment. Having a provider you trust, who is supportive and has empathy, can produce better treatment results.

Help Advance Placebo Research

You may be able to help scientists learn more about the placebo effect:

• To participate in a clinical trial, visit www.clinicaltrials.gov. Use the search terms “placebo effect” or “open-label placebo” and [your state] to find trials in your area.
• Learn about participating in clinical trials.
• Create a volunteer profile for yourself or for someone else as their parent or guardian at ResearchMatch.org
• This NIH-funded resource is a free, secure registry. It keeps you informed of clinical research studies that need volunteers matching your profile.