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Melatonin --Weightloss Link

By cmeletis at Sept. 11, 2015, 9:58 a.m., 6709 hits

Melatonin Related to Postmenopausal Weight Gain

Melatonin deficiency may play a role in postmenopausal weight gain, researchers recently discovered. Previous research shows that melatonin secretion decreases with advancing age with significant changes in women after age 40.

The subjects included 90 pre- and postmenopausal women. The researchers divided the women into three groups: 1) women without menstrual disorders to serve as the control group, 2) postmenopausal women without change in appetite and body weight, and 3) postmenopausal women with increased appetite and weight gain. The investigators measured serum melatonin, 17-beta-estradiol, the pituitary hormone follicular stimulating hormone (FSH), and urine 6-sulfatoxymelatonin, a melatonin metabolite.

The level of melatonin and estradiol were lower and FSH was higher in the postmenopausal women compared to the control group. As body mass index increased, urine 6-sulfatoxymelatonin excretion decreased. The data also showed that FSH levels correlated with body mass index, particularly in the overweight women.

The investigators concluded, “The obtained results indicate a significant effect of melatonin deficiency on the process of weight gain in postmenopausal women and justify its use in treatment of these disorders.”

Walecka-Kapica E, et al. Int J Mol Sci. 2015;16:1030-42. (source: ProTheraInc)

Posts [ 4 ] | Last post Sept. 11, 2015, 9:58 a.m.
#1 - April 2, 2015, 3:03 p.m.

very interesting.. could you tell me where to find the study you are referring to? Thank you Dr. Beth

#2 - April 2, 2015, 5:28 p.m.
Chris D. Meletis, ND

The research abstract and journal information are:

Int J Mol Sci. 2015 Jan 5;16(1):1030-42. doi: 10.3390/ijms16011030.

Melatonin and female hormone secretion in postmenopausal overweight women.
Walecka-Kapica E1, Chojnacki J2, Stępień A3, Wachowska-Kelly P4, Klupińska G5, Chojnacki C6.

Estrogen deficiency is considered to be the main cause of increased appetite and increased weight in postmenopausal women. In this period, reduced secretion of melatonin (MEL) was also observed. The aim of the study was to evaluate the secretion of melatonin, 17-β estradiol and follicle-stimulating hormone (FSH) in relation to body mass index (BMI) in pre- and postmenopausal women. The study included 90 women divided into three equal groups: group I (control)-women without menstrual disorders, group II-postmenopausal women without change in appetite and body weight, group III-postmenopausal women experiencing increased appetite and weight gain. In each patient, serum melatonin, 17-β-estradiol, FSH and urine a 6-sulfatoxymelatonin (aMT6s) were determined. Compared to the control group, the level of melatonin and estradiol was statistically lower. The FSH level was higher than in the groups of postmenopausal women. No significant correlation was found in all groups between the level of melatonin and the levels of estradiol and FSH. A negative correlation was found between aMT6s excretion and BMI, and a positive correlation between the level of FSH and BMI, mainly in overweight women. The obtained results indicate a significant effect of melatonin deficiency on the process of weight gain in postmenopausal women and justify its use in treatment of these disorders.

#3 - April 4, 2015, 12:54 p.m.

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#4 - Sept. 11, 2015, 9:58 a.m.

They're now saying that it may help treat Multiple Sclerosis, as well