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Home » DNA repair

Telomere Restoration Reverses Aging-Related Disease

By dsorbello at Oct. 9, 2013, 7:55 a.m., 8757 hits

Harvard Medical School (US) researchers successfully halt telomere shortening to prompt a reversal of age-related organ atrophy, in a laboratory model of aging.

Telomeres are protective endcaps of DNA, which shorten each time cells divide. Telomere shortening has been linked to the aging process. Ronald A. DePinho, from Harvard Medical School (Massachusetts, USA), and colleagues engineered mice with short telomeres and inactive telomerase to mimic aging. The team then switched telomerase back on, and after four weeks, atrophied tissue had regenerated in several organs, new brain cells were developing, and the mice were living longer. The researchers report that: “Telomerase reactivation in such late generation transcriptase-oestrogen receptor (TERT-ER) mice extends telomeres, reduces DNA damage signalling and associated cellular checkpoint responses, allows resumption of proliferation in quiescent cultures, and eliminates degenerative phenotypes across multiple organs.” Writing that: “Accumulating evidence implicating telomere damage as a driver of age-associated organ decline and disease risk ,” the team submits that: "The marked reversal of systemic degenerative phenotypes in adult mice observed here support the development of regenerative strategies designed to restore telomere integrity.”

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09603.html

 
Posts [ 6 ] | Last post Oct. 9, 2013, 7:55 a.m.
#1 - Jan. 2, 2011, 2:29 p.m.

hello nice thread. I am impressed with information given by you. Natural suplements or products are very much effective in aging related disease. Take care.

#2 - Jan. 6, 2011, 5:30 p.m.
martyeisen

Qigong for Longevity
Posted on August 15, 2010 by martyeisen
Qigong (Chi Kung) is a Chinese medical therapy thousands of years old. It consists of mental as well as physical maneuvering which simultaneously adjust body posture, breathing, and the mind. Qigong for health is not strenuous and can even be performed by handicapped people. It can be done anywhere, at any time, and requires no special clothing or equipment. Qigong is practiced by millions of people worldwide.

The star of the TV show “The Doctor OZ Show” stated, “If you want to be healthy and live to 100, do Qigong.” Dr. Oz was not just making wild speculations. Recent research has found a way to predict and increase your life span. Tips of chromosomes are called telomeres. These protective caps, made of repetitive chunks of DNA, keep the rest of the gene-laden chromosomes from disastrously unraveling. Telomeres length has been linked to life span. Longer telomeres have been associated with longer lives and vice versa. A cell’s telomeres shorten a bit each time that the cell divides. Telomeres length is decreased by stress and can be increased by reducing stress!

Conferences on the scientific study of Qigong have been held in the U.S. and China. Qigong has been shown to improve respiration, induce the relaxation response, cause favorable changes in blood chemistry, and produce changes in EEG indicating improved mental states. Clinical trials have shown the efficacy of Qigong in reducing stress, delaying aging effects, prolonging life, preventing illness and curing many chronic diseases including paralysis and cancer.

Not only can Qigong increase longevity, but also the quality of life. One scientific survey of aged practitioners revealed that they were in good health and appeared younger than a second group of non-practitioners. Their average blood pressure was normal and 93% had normal hearing and good memories. The non-practicing elders had a higher average blood pressure, 25% had hypertension, 50% had vision problems, 76% had hearing problems and 35% had lost their ability to work. After doing Qigong for 5 months, 52% of them could work & made significant physiological improvements.

Qigong for health is excellent for seniors or the physically challenged. It can be done any- where lying, sitting or standing. No equipment is needed. Very little flexibility and coordination are required, making it easier to learn than Yoga. Pilates or Tai Chi. See

http://martyeisen.wordpress.com

for more information on Qigong.

#3 - Oct. 28, 2012, 5:07 a.m.

Although research into this field is extremelly exciting, lengthening Telomeres can create “Immortal Cells”. The problem is that Cancer cells are also “Immortal”, and the possibility of inducing Cancer is very real with this type of therapy.

There needs to be more research for safeguards against inducing Cancer.

#4 - Oct. 28, 2012, 4:43 p.m.
Hans J. Kugler, PhD

Big deal!
So, why didn't this paper - published nearly 2 years ago - get more attention?
Because it is merely cute and, besides showing - again - the functions of telomeres (which had already been established) doesn't say anything really new!
Building a telomerase-deficient mouse - - see how it ages - - , and then reactivating telomerase (- - see how it reverses aging) isn't this more of a show-bizz experiment?
Do it on the real thing - like TA-65 - and I'll be impressed and start yodeling.
All this aging, theories of aging, definition of life-long true health (prof. E. Cheraskin, Alabama U. school of medicine; my long-time mentor), and how to interfere with, and reverse aging, is discussed in detail in LIFE-LONG HEALTH; for more details just click on book cover at http://www.antiagingforme.org .

— Last Edited by Hans J. Kugler, PhD at 2012-10-28 16:48:18 —

#5 - Oct. 30, 2012, 12:14 p.m.
NanoDoc

If the Tissues Become Anoxic from Microvascular Arteriosclerosis, the Cells Die Irrespective Of Telomere Status!


— Last Edited by Greentea at 2012-10-30 12:54:04 —

#6 - Oct. 9, 2013, 7:55 a.m.

Telomerase is a reverse transcriptase able to elongate telomeres during cell that rescue of short telomeres by telomerase is sufficient to restore cell .


Savita Bhabhi Movie

— Last Edited by lucelo at 2013-10-09 07:55:31 —