C) iPS – induced Pluripotent Stem Cells are a type of pluripotent stem cell artificially derived from a non-pluripotent cell, typically an adult somatic cell, by introducing control genes into the adult cell (skin, others) using retroviruses (20, 21). This work in essence originated with the Japanese researcher Dr. Shinya Yamanaka. This is of great scientific interest, but applications for human treatments are many years away for five major reasons: 1) Risk of tumors, 2) Safety because of cancer risk (30, 31), 3) telomere lengthening in iPS is questionable, and 4) Genetic abnormalities were identified in iPS (24). 5) Rejection; iPS rejected by animal from which iPS were made (33).
Would you agree to have such “stem cells” transplanted into your body?
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(20) Yamanaka, K. T. (2006, 8 25). Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Retrieved 12 22, 2009, from Cell: http://www.cell.com/abstract/S0092-8674(06)00976-7
(21) Yamanaka S, et al. | Generation of germline-competent induced pluripotent stem cells | Nature 2007;448:313-7 | PMID 17554338
(24) http://www.sciencedaily.com/releases/2011/01/110106144737.htm .Also
http://www.nature.com/news/2011/110202/full/470013a.html
(30 Establishment of induced pluripotent stem cells from human neonatal tissues. Fujioka T, Shimizu N, Yoshino K, Miyoshi H, Nakamura Y. ) Hum Cell. 2010 Aug;23(3):113-8. doi: 10.1111/j.1749-0774.2010.00091.x. Epub 2010 Oct 1.
(31) Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells. Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, Yu W, Matsui W, Van Criekinge W, Rassool FV, Zambidis E, Schuebel KE, Cope L, Yen J, Mohammad HP, Cheng L, Baylin SB. ) Cancer Res. 2010 Oct 1;70(19):7662-73. Epub 2010 Sep 14.
(33) Yang, Xu, Univ. of San Diego, Rejection of iPS by animal from which iPS were made.
http://www.msnbc.msn.com/id/43023388/ns/health-cloning_and_stem_cells/#.Tk3VP4IpNAm
— Last Edited by Hans J. Kugler, PhD at 2011-12-29 19:35:42 —
