In a paper presented at the 2012 Orlando A4M Congress (to be published in the coming A4M ANTI-AGING MEDICAL THERAPEUTICS textbook), I elaborated on a mechanism that explained why Endocrine Disrupters (similar to toxins associated with GMOs), can have severe, and often irreversible effects, ranging from premature puberty in girls (as young as age 7), smaller penises in boys, diminished performances in athletes, and negated anti-aging protocols in all age groups:
• A messenger chemical – hormone – arrives at the cell wall to transmit a message to the nucleus (DNA, inside the cell) that a certain peptide needs to be synthesized (to trigger an immune response, for example).
• Receptors in the cell wall, where the hormone fits in, accept the message – “Lock and Key” mechanism – and pass it along to the inside. If these receptors are blocked by an endocrine disrupter (hormone mimic), the message can’t get passed along, or it starts a wrong chain of reactions that are not required.
• If the message gets past along to the inside of the cell, a prostaglandin inside the cell picks up the message and transmits it to the nucleus. However, endocrine-disrupters can also interfere with prostaglandin synthesis, and if this happens, the message is interrupted again;
• If the message makes it to the DNA, based on the message carried by the prostaglandin, a gene on the DNA (that contains information about how to make the protein/peptide) is copied, resulting in an m-RNA (messenger RNA);
• The m-RNA travels to the r-RNA (ribosomal RNA, the workbench equivalent inside the cell) where the protein is assembled;
• t-RNAs (transfer-RNAs) – a different one for each amino acid – bring the amino acids to the workbench;
• The protein is assembled in the correct shape and fold – recall prions, the cause of mad cow disease, these are incorrectly folded proteins.
The major response – mostly from supporters of fracking, environmental polluters, Monsanto and GMO stock holders (who else would support such Frankenfoods?) – used to be “well, you have some points there, but this (the lock and key receptors in the cell membrane, passing messages along to the inside in the cell, and then to the nucleus) is far from proven!”
The opponent’s arguments were silenced with the 2012 Nobel Prize for chemistry given to Drs. Robert Lefkowitz (Duke U) and Brian Kobilka (Stanford), showing that the pathway really is a “lock-and-key” mechanism; they call the receptors in the cell membrane that accept a message outside, and then pass it on in the inside “G-protein-coupled receptors”, or GPCRs (it’s like a lock and key, Lefjkowitz said).
Problems, started by endocrine disrupters and/or toxins associated with GMOs, can be extremely severe, numerous, and irreversible. At present, two areas of research show promise: detoxing and NT stem cells. For details see Ch. 4 and 12 in my most recent e-book “LIFE-LONG HEALTH: learn how to Control your Genes to stay Young with Age.” For access to the first 22 pages, and where to purchase at a non-profit price, click on book cover at http://www.antiagingforme.org .
— Last Edited by Hans J. Kugler, PhD at 2012-10-27 14:47:38 —
— Last Edited by Hans J. Kugler, PhD at 2012-10-27 14:48:25 —
— Last Edited by Hans J. Kugler, PhD at 2012-10-27 14:49:39 —
— Last Edited by Hans J. Kugler, PhD at 2012-10-27 15:01:50 —
— Last Edited by Hans J. Kugler, PhD at 2012-10-28 15:47:21 —