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Cardio-Vascular Awareness Genetic Research Heart Health

Anger and Your Heart: More Reasons to Learn Some Ways to Chill Out

1 month, 2 weeks ago

2157  0
Posted on Jun 05, 2024, 2 p.m.

Article courtesy of Dr. Joel Kahn, MD, who is a Clinical Professor of Medicine at Wayne State University School of Medicine, one of the world's top cardiologists, a best-selling author, lecturer, and a leading expert in plant-based nutrition and holistic care.

Everyone has heard of someone angry, yelling, and then dropping dead. Why? Provoked anger is associated with an increased risk of cardiovascular disease events. The underlying mechanism linking provoked anger as well as other core negative emotions including anxiety and sadness to cardiovascular disease remains unknown.

The study objective was to examine the acute effects of provoked anger and secondarily, anxiety and sadness on endothelial cell health.


Apparently, healthy adult participants (n=280) were randomized to an 8‐minute anger recall task, a depressed mood recall task, an anxiety recall task, or an emotionally neutral condition.

Pre−/post‐assessments of endothelial health including endothelium‐dependent vasodilation, circulating endothelial cell‐derived microparticles, and circulating bone marrow‐derived endothelial progenitor cells were measured.

There was a group×time interaction for the anger versus neutral condition on the change in reactive hyperemia index score from baseline to 40 minutes. For the change in reactive hyperemia index score, the anxiety versus neutral condition group by time interaction approached but did not reach statistical significance.

There were no consistent statistically significant group×time interactions for the anger, anxiety, and sadness versus neutral condition on endothelial cell‐derived microparticles and endothelial progenitor cells from baseline to 40 minutes.

The researchers found blood vessels’ ability to dilate was significantly reduced among people in the angry group compared with those in the control group. Blood vessel dilation wasn’t affected in the sadness and anxiety groups.

Dilation can be regulated by endothelial cells, which line the insides of blood vessels. By dilating and contracting, blood vessels slow down or increase the blood flow to the parts of the body that need it. 

Further tests revealed that there was no damage to the endothelial cells or to the body’s ability to repair any endothelial cell damage. 


In this randomized controlled experimental study, a brief provocation of anger adversely affected endothelial cell health by impairing endothelium‐dependent vasodilation.

The results of the study could help physicians persuade their patients to manage their anger, through yoga, exercise, cognitive behavioral therapy or other established techniques.

About the author: At his core, Dr. Joel Kahn believes that plant-based nutrition is the most powerful source of preventative medicine on the planet. Having practiced traditional cardiology since 1983, it was only after his own commitment to a plant-based vegan diet that Dr. Kahn truly began to delve into the realm of non-traditional diagnostic tools, prevention tactics, and nutrition-based recovery protocols.

As with anything you read on the internet, this article should not be construed as medical advice; please talk to your doctor or primary care provider before changing your wellness routine. This article is not intended to provide a medical diagnosis, recommendation, treatment, or endorsement. These statements have not been evaluated by the Food and Drug Administration. 

Content may be edited for style and length.

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