Posted on May 22, 2013, 6 a.m.
Triterpenoids extracted from apple peel may influence expression of IP-10, a gene that is linked to inflammatory disorders including irritable bowel disease.
Apple peel is an abundant source of triterpenoids – plant-based compounds for which anti-cancer effects are suggested. Elke Richling, from University of Kaiserslautern (Germany), and colleagues studied the effects of ursanic, oleanic and lupanic pentacyclic triterpenoids found in apple peel for their anti-inflammatory effects, using colon cancer cells that were exposed to the triterpenoids and then stimulated with pro-inflammatory cytokines. Finding that the apple peel compounds inhibited the expression of IP-10, a gene that is linked to inflammatory disorders including irritable bowel disease, the study authors submit that: “The present study confirms that triterpenoids present in apple peel … may be implicated in the anti-inflammatory properties of apple constituents, suggesting that these substances might be helpful in the treatment of [irritable bowel disease] as nutrient supplements.”
Dolores Mueller, Sven Triebel, Olga Rudakovski, Elke Richling. “Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD).” Food Chemistry, Volume 139, Issues 1–4, 15 August 2013, Pages 339-346.