Breakthrough Discovery Brings Lung Regeneration A Step Closer6 years, 12 months ago
Posted on Nov 21, 2011, 6 a.m.
Researchers from Weill Cornell Medical College(US) reports their discovery of biochemical signals that trigger the generation of new lung alveoli.
Potentially opening the door to a regenerative therapy for lung disorders. researchers from Weill Cornell Medical College (New York, USA) report their discovery of biochemical signals that trigger the generation of new lung alveoli, the numerous, tiny, grape-like sacs within the lung where oxygen exchange takes place, in a lab animal model. Specifically, the regenerative signals originate from the specialized endothelial cells that line the interior of blood vessels in the lung. While it has long been known that mice can regenerate and expand the capacity of one lung if the other is missing, this study now identifies molecular triggers behind this process, and the researchers believe these findings are relevant to humans.
Bi-Sen Ding, Daniel J. Nolan, Peipei Guo, Alexander O. Babazadeh, Zhongwei Cao, Zev Rosenwaks, Shahin Rafii, et al. “Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization.” Cell, 147(3) pp. 539 – 553.