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Mechanisms of Aging

Cellular Aging May be Accelerated by Physical or Emotional Trauma in Childhood

14 years, 4 months ago

8197  0
Posted on Dec 01, 2009, 7 a.m.

Brown University (USA) researchers identify an accelerated reduction of telomere length in those who experienced physical or emotional trauma in childhood.

Audrey Tykra, from Brown University (Rhode Island, USA), and colleagues have determined that children who suffer physical or emotional abuse may be faced with accelerated cellular aging as adults, the consequence resulting from shortened telomeres  -- the endcaps on chromosomes that are thought to govern the number of times a cell can divide. The researchers extracted DNA from blood samples of 31 adults, finding an accelerated shortening of telomeres in those who reported suffering maltreatment as children, compared to study participants who did not.  Specifically, the team observed a “[d]ampened cortisol reactivity [that] might be a consequence of childhood [emotional abuse] that is cumulative over time.”

Linda L. Carpenter, Audrey R. Tyrka, Nicole S. Ross, Lamya Khoury, George M. Anderson, Lawrence H. Price.  “Effect of Childhood Emotional Abuse and Age on Cortisol Responsivity in Adulthood.”  Biological Psychiatry, Volume 66, Issue 1, 1 July 2009, Pages 69-75.

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