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Functional Foods Genetics in Disease

Coffee May Protect from DNA Damage

8 years ago

907  0
Posted on Sep 28, 2010, 6 a.m.

European team reports that a daily cup of coffee helps to minimize the oxidative damage to DNA.

Among the most frequently consumed beverages worldwide, coffee is rich in antioxidants, with one cup providing 350 mg of phenolic compounds.  A team of researchers from the University of Vienna (Austria), the University of Belgrade (Serbia), and other European institutions enrolled 38 men and women for a controlled intervention trial with a cross-over design. Each subject consumed 800 ml of paper-filtered coffee or water daily over 5 days. The researchers found that coffee reduced the oxidative damage to DNA, as measured by a decreased formation of oxidized purines, by 12.3%. No significant changes in levels of antioxidants in the blood, or levels of reactive oxygen species in the blood, were observed.  The team concludes that: “Overall, the results indicate that coffee consumption prevents endogenous formation of oxidative DNA-damage in human, this observation may be causally related to beneficial health effects of coffee seen in earlier studies.”

Miroslav Misik, Christine Hoelzl, Karl-Heinz Wagner, Christophe Cavin, Beate Moser, Michael Kundi, Tanja Simic, Leonilla Elbling, Nina Kager, Franziska Ferk, Veronika Ehrlich, Armen Nersesyan, Maria Dusinska, Benoit Schilter, Siegfried Knasmuller.  “Impact of paper filtered coffee on oxidative DNA-damage: Results of a clinical trial.”  Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 13 August 2010.

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