Anti-Aging Research Science
Genetic modulation of soluble A[beta] rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease
9 years, 10 months ago
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Posted on Jun 17, 2014, 3 p.m.
Effect of soluble A[beta] from that of deposited amyloid on cognitive function and synaptic structure [mouse]
Rapid inhibition of transgenic amyloid precursor protein (APP) modulates the production of A[beta] without affecting pre-existing amyloid deposits and restored cognitive performance to the level of healthy controls.
Fowler SW, Chiang AC, Savjani RR, Cirrito JR, Lesne SE, Jankowsky JL, et al. J Neurosci. 2014 Jun 4;34(23):7871-85.
