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Cellular Reprogramming

Novel Technique Advances Cell Therapy to Treat Disease

5 years, 6 months ago

141  0
Posted on Jan 12, 2012, 6 a.m.

A new way to deliver therapeutic human cells to diseased areas paves the way towards effectively using cell therapy to treat a variety of disorders.

Cell therapy is a technique whereby healthy normal cells or stem cells are infused into the body to treat disease.  In that cell therapy aims to replace damaged or diseased cells in the human body with normal cells or stem cells, it is necessary that scientists accurately target these therapeutic cells to diseased organs or tissues. In a discovery that may help speed use of cell therapy, French scientists reported their development of a way to deliver these therapeutic cells to diseased areas within the body using a simple magnetic effect.  Rawil Fakhrullin, from Ecole Normale Superieure (France), and colleagues have devised a process to make "stabilized" superparamagnetic iron oxide nanoparticles (SPIONs) in the laboratory, which are then attached to therapeutic cells. Their technique did not introduce toxicity, and enabled their delivery by a magnetic effect.  Observing that: “The magnetically responsive cells are viable and able to colonize and grow on substrates. Magnetically facilitated microorganization of functionalized cells into viable living clusters is demonstrated,” the study authors conclude that: “The technique described here may find a number of potential applications in cell-based therapies and in development of whole-cell biosensors.”

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Dzamukova MR, Zamaleeva AI, Ishmuchametova DG, Osin YN, Kiyasov AP, Nurgaliev DK, Ilinskaya ON, Fakhrullin RF.  “A direct technique for magnetic functionalization of living human cells.”  Langmuir. 2011 Dec 6;27(23):14386-93.

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