Posted on Dec 08, 2016, 6 a.m.
Oleocanthal kills cancer cells by rupturing vesicles that store cellular waste, in a cell culture model.
Extra virgin olive oil is abundant in oleocanthal, a compound for which previous studies have suggested heart-healthy benefits. David Foster, from Hunter College (New York, USA), and colleagues employed a cell culture model to study the effects of oleocanthal on human cancer cell lines. The team observed that “[oleocanthal] induced cell death in all cancer cells examined – as rapidly as 30 minutes after treatment …”, by inducing lysosomal membrane permeabilization to result in a rupturing of vesicles that store cellular waste. The study authors submit that: “targeting lysosomal membrane stability represents a novel approach to induce cancer-specific cell death.”
O LeGendre, P A S Breslin & D A Foster. “Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization (LMP).” Molecular & Cellular Oncology, 23 Jan. 2015.