Anti-Aging Research Science
Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
9 years, 8 months ago
10933
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Posted on Aug 18, 2014, 12 p.m.
Genome-editing reduces cholesterol [mouse]
Nicotinamide riboside, a vitamin B3, is effective to delayed early- and late-stage disease progression, via mitochondrial biogenesis in skeletal muscle and brown adipose tissue, thereby preventing mitochondrial ultrastructure abnormalities and mtDNA deletion formation. NR further stimulated mitochondrial unfolded protein response, suggesting its protective role in mitochondrial disease.
Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsstrom S, Pasila L, Velagapudi V, Carroll CJ, Auwerx J, Suomalainen A. EMBO Mol Med. 2014 Apr 6;6(6):721-31.
