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Anti-Aging Research Science Alzheimer's Disease Neurology

Potential Protective Effects of Hops Compound

3 years, 10 months ago

3858  0
Posted on Mar 05, 2015, 6 a.m.

Xanthohumol, a type of flavonoid found in hops and beer, may exert protective effects against Alzheimer’s and other neurodegenerative diseases.

A flavonoid found in hops and beer, xanthohumol has been reported to ameliorate a cellular process involved in cognitive flexibility (see http://www.worldhealth.net/news/hops-compound-may-improve-cognitive-skills/ ).  Jianguo Fang, from Lanzhou University  (China), and colleagues conducted lab tests that recveal that xanthohumol protects neuronal cells, observing that the compound “significantly upregulates a panel of phase II cytoprotective genes as well as the corresponding gene products, such as glutathione, heme oxygenase, NAD(P)H:quinone oxidoreductase, thioredoxin, and thioredoxin reductase.”  The study authors submit that xanthohumol “might be a potential candidate for the prevention of neurodegenerative disorders.”

Yao J, Zhang B, Ge C, Peng S, Fang J.  “Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells.”  J Agric Food Chem. 2015 Jan 28.

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