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Hormones & Pharmacological Agents Mitochondria

Pregnelonone

13 years, 1 month ago

1689  0
Posted on Dec 30, 2005, 8 p.m. By Bill Freeman

GENERAL DESCRIPTION: Produced in the mitochondria throughout the body from cholesterol, pregnenolone is the base material of all human steroid manufacture, including DHEA, progesterone, testosterone, and estrogen. It appears to block the effects of cortisol, thus helping to prevent stress-mediated cell injury.

GENERAL DESCRIPTION:

Produced in the mitochondria throughout the body from cholesterol, pregnenolone is the base material of all human steroid manufacture, including DHEA, progesterone, testosterone, and estrogen. It appears to block the effects of cortisol, thus helping to prevent stress-mediated cell injury. Pregnenolone stimulates brain NMDA receptors. These receptors, which decline with age, play an important role in the function of synapses and neurons, influencing learning and memory. Pregnenolone levels are directly correlated with cognitive ability. Pregnenolone levels decline with age.

ROLE FOR ANTI-AGING:

Pregnenolone’s anti-aging benefits may include reduction of stress, reduction of arthritic inflammation, potential maintenance of memory capability, improved mood, positive outlook and well-being and improved sleep patterns.

DEFICIENCY SYMPTOMS:

Pregnenolone is not associated with a deficiency state.

THERAPEUTIC DAILY AMOUNT:

The typical recommended dose of pregnenolone is 30mg, however some studies have used as much as 700mg per day. Pregnenolone is available in 5mg, 10mg, 20mg, 25mg, 30mg, 50mg, and 100mg capsules.

MAXIMUM SAFE LEVEL: Not established

SIDE EFFECTS/CONTRAINDICATIONS:

There have reports of rash occurring with use but otherwise there are few side effects. Pregnant and nursing women, children, and people with kidney or liver disease should not take pregnenolone. In people with prostate conditions, use of pregnenolone should be monitored carefully.

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