Rejuvenation of the muscle stem cell population restores strength to injured aged muscles4 years, 5 months ago
Posted on Apr 02, 2014, 3 p.m.
A higher incidence of aging skeletal muscle stem cells express senescence markers due to elevated activity of the p38[alpha] and p38[beta] mitogen-activated kinase pathway [mouse]
Subjecting the skeletal muscle stem cells population from aged mice to transient inhibition of p38[alpha] and p38[beta] in conjunction with culture on soft hydrogel substrates rapidly expands the residual functional skeletal muscle stem cells population from aged mice, rejuvenating its potential for regeneration and serial transplantation as well as strengthening of damaged muscles of aged mice.
Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM. Nat Med. 2014 Mar;20(3):255-64.