Posted on Jan 10, 2013, 6 a.m.
Meta-analysis involving 91,000+ subjects reports that taking a daily multivitamin/multimineral supplement does not raise the risk of death.
Whereas multivitamins are the most commonly used supplement in the developed world, a number of recently published studies have differed regarding whether multivitamin/multimineral supplementation increases the risk of mortality. H. Macpherson, from Swinburne University (Australia), and colleagues completed a meta-analysis of randomized controlled primary or secondary prevention trials that investigated daily multivitamin/multimineral supplementation for 1 year or longer. In total, 21 articles were included in the analysis, which generated a total pooled sample of 91,074 subjects (average age 62 years). The researchers observed that taking a daily multivitamin/multimineral supplement does not raise the risk of all-cause mortality, or mortality specifically from cancer or vascular causes. Further, the team found a trend for a reduced risk of all-cause mortality across primary prevention trials. The study authors conclude that: “multivitamin-multimineral treatment has no effect on mortality risk.”
Macpherson H, Pipingas A, Pase MP. “Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials.” Am J Clin Nutr. 2012 Dec 19.