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Hormones & Pharmacological Agents

Yohimbine

13 years, 8 months ago

2261  0
Posted on Dec 30, 2005, 8 p.m. By Bill Freeman

GENERAL DESCRIPTION: Yohimbine is a pharmaceutical preparation derived from the bark of a tree, called the Corynanthe yohimbine, which has been useful in the treatment of impotence. Yohimbine acts upon the alpha 2 adrenergic nerve cells and blocks their receptiveness to neurotransmitter activity.

GENERAL DESCRIPTION:

Yohimbine is a pharmaceutical preparation derived from the bark of a tree, called the Corynanthe yohimbine, which has been useful in the treatment of impotence. Yohimbine acts upon the alpha 2 adrenergic nerve cells and blocks their receptiveness to neurotransmitter activity. It is theorized that inhibition of these cells increases the blood flow through the penis, while at the same time reducing the flow of blood from the penis. Furthermore, yohimbine increases blood levels of the neurotransmitter norepinephrine, one of the body’s own prosexual chemicals affecting the hypothalamus. Yohimbine may also increase levels of acetylcholine, a neurotransmitter that has an effect on male erection response.

ROLE FOR ANTI-AGING:

The anti-aging benefits of yohimbine are purported to be the improvement of strength, duration and response of male erection, libido enhancement and improved sexual performance.

SIDE EFFECTS/CONTRAINDICATIONS:

Yohimbine is likely to be more sensitive in the elderly, where it can lead to over stimulation to the point of nervousness and anxiety. Other side effects may include nausea, vomiting, increased blood pressure, tremors, dizziness and headaches. Patients with inflammatory disease of the urogenital tract, known or suspected prostate or mammary cancer, hypercalciuria, hypercalcemia, nephritic syndrome, ischemic heart disease, untreated congestive heart failure, glaucoma, extrapyramidal disorders and hyperexcitable states should avoid yohimbine. Although not generally used by women, yohimbine should not be taken during pregnancy. Yohimbine is classified as a monoamine-oxidase (MAO) inhibitor, therefore people taking it should avoid foods containing tyramine, for example red wine, cheese,and dark chocolate. It should also not be taken alongside the amino acids tyrosine and phenylalanine (many soft drinks contain phenylalanine).

Yohimbine should not be used by people taking diet aids or nasal decongestants containing the drug phenylpropanolamine. People with a history of angina pectoris, mental depression or any other psychiatric illness, heart disease, high blood pressure, or impaired kidney function, should consult their doctor before taiking yohimbine.

Distribution: Yohimbine is available in 1mg, 2.5mg, 5mg and 10mg tablets under the trade manes Aphrodyne, Dayto Himbin, Plain Prowess, Yocon and Yohimes.

PHARMACOLOGY:

Synonyms: Aphrodine Hydrochloride; Chlorhydrate de Quebrachin; Corynine Hydrochloride.

Chemical Name: Methyl 17alpha hydroxy yohimban-16alphacarboxylate hydrochloride.

Molecular Formula: C(21)H(26)N(2)O(3),HCL

Molecular Weight: 390.9

Note: Yohimbine is a pharmaceutical preparation derived from the bark of a tree, called the Corynanthe yohimbine. it should not be confused with Yohimbe, which although is often the ground down bark of this tree, is not a pharmaceutical preparation and likely to contain a minute amount of Yohimbine.

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