Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans
10 years, 1 month ago
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Posted on Apr 01, 2014, 3 p.m.
A strong coupling exists between mitochondrial function and ageing by in vivo visualization of the mitochondrial flash (mitoflash) [roundworm]
Day-3 mitoflash frequency is a powerful predictor of lifespan across genetic, environmental and stochastic factors, and suggests that the rate of ageing, although adjustable in later life, has been set to a considerable degree before reproduction ceases.
Shen EZ, Song CQ, Lin Y, Zhang WH, Su PF, Liu WY, Zhang P, Xu J, Lin N, Zhan C, Wang X, Shyr Y, Cheng H, Dong MQ. Nature. 2014 Feb 12.