IGF-1 receptor regulates lifespan and resistance to oxidative...

Posted on 2003-04-26 14:15:42 in (HGH) Clinical Research Abstracts |

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.

Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode components of the insulin or insulin-like signalling pathways. Examples include the related tyrosine kinase receptors InR (Drosophila melanogaster) and DAF-2 (Caenorhabditis elegans) that are homologues of the mammalian insulin-like growth factor type 1 receptor (IGF-1R). To investigate whether IGF-1R also controls longevity in mammals, we inactivated the IGF-1R gene in mice (Igf1r). Here, using heterozygous knockout mice because null mutants are not viable, we report that Igf1r( /-) mice live on average 26% longer than their wild-type littermates (P < 0.02). Female Igf1r( /-) mice live 33% longer than wild-type females (P < 0.001), whereas the equivalent male mice show an increase in lifespan of 16%, which is not statistically significant. Long-lived Igf1r( /-) mice do not develop dwarfism, their energy metabolism is normal, and their nutrient uptake, physical activity, fertility and reproduction are unaffected. The Igf1r( /-) mice display greater resistance to oxidative stress, a known determinant of ageing. These results indicate that the IGF-1 receptor may be a central regulator of mammalian lifespan.


Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y.
Nature 2003 Jan 9;421(6919):182-7
Institut National de la Sante et de la Recherche Medicale U515, Hopital Saint-Antoine, 75571 Paris 12, France. holzenberger@st-antoine.inserm.fr
PMID: 12483226 [PubMed - indexed for MEDLINE]

 


Health Headlines

In a lab animal model, booming gut flora spawned by the Western diet is linked to obesity.
International study reaffirms importance of resolving the income gap between the richest and poorest people in developed countries.
Switzerland-based research team assesses the metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress hormones.
UCLA researchers find disability rates in Americans entering their 60s are on the rise, potentially fueled by the overweight/obesity epidemic.
Genetic clues to longevity discovered among a homogenous ethnic population.
Rush Alzheimer's Disease Center (USA) researchers find that a loss of muscle strength raises risk of Alzheimer’s Disease and mild cognitive impairment.
Stroke risk may rise in those with common infectious pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and herpes simplex viruses.
First study in humans links bisphenol A (BPA) exposure to male sexual function problems.
Simple steps in the community can promote walking among residents.
Study finds that people who are dissatisfied with their workplace bosses not only take more sick leave, but are at increased risk of suffering a heart attack.
Looking for an Anti-aging Doctor?

upcoming Events

U.S. Events
congresses
Las Vegas
fellowships
fellowships
symposium
workshops
  • Advanced Hormone Symposium
    Chicago, IL | Oct. 8-10, 2010

VIDEO: Brain Age Workshop
Dr. Eric Braverman, Director of The Place for Achieving Total Health (PATH Medical), Chairs the Brain Age Workshop taking place Dec. 9, 2009. Held in conjunction with the Winter Session of the 17th Annual World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies. The Brain Age Workshop features presentations on Brain Mind Assessment via Neuropsychological Analysis, Movement Deficiency Syndrome, Hormones and the Brain, Nootropic Drug Mechanisms, and Traumatic Brain Injury. View this video to learn about Dr. Braverman’s brain-based model of aging and age modulation.

International Events
See all events »