Regulation of insulin-like growth factor-I ...

Posted on 2003-04-26 14:06:22 in (HGH) Clinical Research Abstracts |

Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells.

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are potent regulators of muscle mass. Transgenic mice that over-express these proteins exhibit dramatically enlarged skeletal muscles. In contrast, malnutrition, critical illness, sepsis, and aging are all associated with a dramatic reduction in muscle mass and function. The circulating concentration of IGF-I and the expression of IGF-I in skeletal muscle are also reduced during catabolic states. Consequently, GH has been used clinically to increase lean body mass in patients with muscle wasting. Likewise, delivery of IGF-I specifically into muscle has been proposed as a genetic therapy for muscle disorders. A better understanding of the regulation of IGF-I expression in skeletal muscle and muscle cells is therefore of importance. Yet, our knowledge in this area has been limited by a lack of GH responsive muscle cells. In addition the IGF-I gene spans over 90 kb of genomic DNA and it exhibits a very complex regulatory pattern. This review will summarize our knowledge of the control of muscle mass by GH, IGF-I, anabolic steroids, exercise and other growth enhancing hormones. We will also highlight recent advances in the regulation of IGF-I and signal transducers and activators of transcription (Stats) by GH. A special emphasis will be placed on the interaction of IGF-I and proinflammatory cytokines in skeletal muscle and muscle cells.


Frost RA, Lang CH.
Minerva Endocrinol 2003 Mar;28(1):53-73
Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University Hershey, PA, USA.
PMID: 12621363 [PubMed - in process]

 


Health Headlines

Gut Bacteria May Promote Weight Gain
In a lab animal model, booming gut flora spawned by the Western diet is linked to obesity.
Reduce Income Inequalities to Save Millions of Lives and Improve Quality of Life
International study reaffirms importance of resolving the income gap between the richest and poorest people in developed countries.
Chocolate May Slash Stress
Switzerland-based research team assesses the metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress hormones.
Among Youngest Older Americans, Disability on the Rise
UCLA researchers find disability rates in Americans entering their 60s are on the rise, potentially fueled by the overweight/obesity epidemic.
Living to 100 Linked to Variant of Telomere Enzyme
Genetic clues to longevity discovered among a homogenous ethnic population.
Keep Muscles Strong to Slash Risk of Cognitive Decline
Rush Alzheimer's Disease Center (USA) researchers find that a loss of muscle strength raises risk of Alzheimer’s Disease and mild cognitive impairment.
Cumulative Exposure to Common Infections May Raise Risk of Stroke
Stroke risk may rise in those with common infectious pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and herpes simplex viruses.
Chemical Present in Plastic Bottles, Canned Products Linked to Male Reproductive Problems
First study in humans links bisphenol A (BPA) exposure to male sexual function problems.
Promote Walking to Encourage Healthy Habits
Simple steps in the community can promote walking among residents.
Poor Leadership at Work Can Make Employees Sick
Study finds that people who are dissatisfied with their workplace bosses not only take more sick leave, but are at increased risk of suffering a heart attack.
Looking for an Anti-aging Doctor?

upcoming Events

U.S. Events
congresses
Las Vegas
fellowships
fellowships
symposium
workshops
  • Advanced Hormone Symposium
    Chicago, IL | Oct. 8-10, 2010

VIDEO: Brain Age Workshop
Dr. Eric Braverman, Director of The Place for Achieving Total Health (PATH Medical), Chairs the Brain Age Workshop taking place Dec. 9, 2009. Held in conjunction with the Winter Session of the 17th Annual World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies. The Brain Age Workshop features presentations on Brain Mind Assessment via Neuropsychological Analysis, Movement Deficiency Syndrome, Hormones and the Brain, Nootropic Drug Mechanisms, and Traumatic Brain Injury. View this video to learn about Dr. Braverman’s brain-based model of aging and age modulation.

International Events
See all events »