AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner4 years, 5 months ago
Posted on Sep 17, 2014, 2 p.m.
UCLA biologists delay the aging process by 'remote control' [fruitfly]
Activating a gene called AMPK in the nervous system induces the anti-aging cellular recycling process of autophagy in both the brain and intestine. Activating AMPK in the intestine leads to increased autophagy in both the intestine and brain. This 'inter-organ' communication during aging can substantially prolong the healthy lifespan of fruit flies.
Matthew Ulgherait, Anil Rana, Michael Rera, Jacqueline Graniel, David W. Walker. Cell Reports, 4 September 2014.