Posted on Jun 28, 2010, 6 a.m.
Tufts University (US) researchers find that higher HDL (“good”) cholesterol levels associate with lower cancer risk.
In that epidemiologic studies suggest an inverse relationship between serum total cholesterol levels and incident cancer. Haseeb Jafri , from Tufts University School of Medicine (Massachusetts, USA), and colleagues have previously reported that lower levels of LDL (low-density lipoprotein, “bad”) cholesterol are associated with a significantly higher risk of incident cancer. The team now finds that higher HDL (high-density lipoprotein, “good”) cholesterol levels associate with lower cancer risk. Conducting a meta-analysis of clinical trials involving lipids interventions, the team assessed data from 24 studies and found “a significant inverse association between baseline HDL-C levels and the rate of incident cancer,” which persisted despite adjustments for confounding factors, such as LDL cholesterol, age, body mass index, sex, and smoking. Specifically, for each 10 mg/dL higher increment of HDL cholesterol, there was a 36% lower relative risk of incident cancer.
Haseeb Jafri, Alawi A. Alsheikh-Ali, Richard H. Karas. “Baseline and On-Treatment High-Density Lipoprotein Cholesterol and the Risk of Cancer in Randomized Controlled Trials of Lipid-Altering Therapy.” J. Am. Coll. Cardiol., June 22, 2010; 55: 2846 - 2854.