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Cancer Fatty Acids, Lipids & Oils Genetic Research

An Omega-3 That’s Poison For Tumors

1 month, 3 weeks ago

3765  0
Posted on Jun 11, 2021, 2 p.m.

  • 3D tumours that disintegrate within a few days thanks to the action of a well-known Omega-3 (DHA, found mainly in fish) – this is the exceptional discovery by University of Louvain (UCLouvain) researchers, published in the prestigious scientific journal Cell Metabolism
  • Hungry for fatty acids, tumour cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die.
  • What’s so original about the discovery? The result of a collaboration between bioengineers specializing in nutrition and cancer specialists, it creates new possibilities for fighting cancer

So-called “good fatty acids” are essential for human health and much sought after by those who try to eat healthily. Among the Omega-3 fatty acids, DHA or docosahexaenoic acid is crucial to brain function, vision, and the regulation of inflammatory phenomena.

In addition to these virtues, DHA is also associated with a reduction in the incidence of cancer. How it works is the subject of a major discovery by a multidisciplinary team of University of Louvain (UCLouvain) researchers, who have just elucidated the biochemical mechanism that allows DHA and other related fatty acids to slow the development of tumours. This is a major advance that has recently been published in the prestigious journal Cell Metabolism.

Key to the discovery: interdisciplinarity

In 2016, Olivier Feron’s UCLouvain team, which specializes in oncology, discovered that cells in an acidic microenvironment (acidosis) within tumours replace glucose with lipids as an energy source in order to multiply. In collaboration with UCLouvain’s Cyril Corbet, Prof. Feron demonstrated in 2020 that these same cells are the most aggressive and acquire the ability to leave the original tumour to generate metastases. Meanwhile, Yvan Larondelle, a professor in the UCLouvain Faculty of Bioengineering, whose team is developing improved dietary lipid sources, proposed to Prof. Feron that they combine their skills in a research project, led by Ph.D. candidate Emeline Dierge, to evaluate the behaviour of tumour cells in the presence of different fatty acids.

Thanks to the support of the Fondation Louvain, the Belgian Cancer Foundation and the Télévie telethon, the team quickly identified that these acidotic tumour cells responded in diametrically opposite ways depending on the fatty acid they were absorbing. Within a few weeks, the results were both impressive and surprising. “We soon found that certain fatty acids stimulated the tumour cells while others killed them,” the researchers explained. DHA literally poisons them.

A fatal overload

The poison acts on tumour cells via a phenomenon called ferroptosis, a type of cell death linked to the peroxidation of certain fatty acids. The greater the amount of unsaturated fatty acids in the cell, the greater the risk of their oxidation. Normally, in the acidic compartment within tumours, cells store these fatty acids in lipid droplets, a kind of bundle in which fatty acids are protected from oxidation. But in the presence of a large amount of DHA, the tumour cell is overwhelmed and cannot store the DHA, which oxidizes and leads to cell death. By using a lipid metabolism inhibitor that prevents the formation of lipid droplets, researchers were able to observe that this phenomenon is further amplified, which confirms the identified mechanism and opens the door to combined treatment possibilities.

For their study, UCLouvain researchers used a 3D tumour cell culture system, called spheroids. In the presence of DHA, spheroids first grow and then implode. The team also administered a DHA-enriched diet to mice with tumours. The result: tumour development was significantly slowed compared to that in mice on a conventional diet.

This UCLouvain study shows the value of DHA in fighting cancer. “For an adult,” the UCLouvain researchers stated, “it’s recommended to consume at least 250 mg of DHA per day. But studies show that our diet provides on average only 50 to 100 mg per day. This is well below the minimum recommended intake.”

As with anything you read on the internet, this article should not be construed as medical advice; please talk to your doctor or primary care provider before making any changes to your wellness routine.

Content may be edited for style and length

Materials provided by:

https://uclouvain.be/en/discover/press/news/an-omega-3-that-s-poison-for-tumours.html

http://dx.doi.org/10.1016/j.cmet.2021.05.016

https://www.sciencedirect.com/science/article/pii/S1550413121002333?dgcid=author

https://cdn.uclouvain.be/groups/cms-editors-presse/cp-juin-2021/11-06-2021_UCLouvain_press_release_omega3_poison_tumeurs_Embargo11-06_17h-EN.pdf

emeline.dierge@uclouvain.be

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