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Adderall is a psychostimulant, a drug from the class of phenethylamines, used in some countries in the treatment of attention deficit and hyperactivity and narcolepsy. Also used illegally as a cognitive enhancer, both an aphrodisiac and for the sake of a euphoric effect. The drug is a mixture of two amphetamine salts, stereoisomers and inactive components. Salts are the active ingredients distributed as follows: 75% Dextroamphetamine (right-rotary isomer) and 25% Levamphetamine (left-handed isomer).
Adderal works by increasing the activity of the neurotransmitters norepinephrine and dopamine in the brain. Adderall duplicates many of the chemical and pharmacological reactions of endogenous neurotransmitters, especially phenethylamine and methylphethylamine, the latter isomer of amphetamine, which is produced in humans.
Adderall is generally well tolerated and effective in treating the symptoms of ADHD. The most common side effects are cardiovascular, such as, increased heart rate, and psychological, such as euphoria or anxiety. Large doses of the drug are likely to impair cognitive function and cause rapid muscle breakdown. Drug addiction is a serious risk of abuse of adderalla, but only in rare cases occurs with therapeutic use. Very high doses can lead to a psychotic state (for example, delirium and paranoia), which is rarely seen with a therapeutic dosage even with prolonged use.
Studies using magnetic resonance imaging (MRI) show that long-term drug treatment leads to a decrease in abnormalities in the brain structure and functions in patients with ADHD, improves the performance of certain brain regions, such as the caudate nucleus in the basal ganglia.
Current models of ADHD suggest that this is due to functional impairment in some mediator systems, including a decrease in dopamine neurotransmission in the mesocorticolimbus region and norepinephrine in the synapses in the blue spot and the prefrontal cortex.
Adderall is available in immediate-release tablets or sustained-release capsules.
Therapeutic doses of the drug increase productivity in solving both complex and repetitive tasks. Higher dosages disrupt short-term memory and cognitive processes.
Increases endurance and reaction time, primarily due to inhibition of dopamine reuptake.
In order to abuse the drug, the tablets are crushed and sniffed, less commonly dissolved in water and injected. The latter route of administration is extremely dangerous, since the ballast substances contained in the tablets can cause obliteration of peripheral blood vessels.
Contraindications
Drug abuse, heart disease, neurotic diseases, atherosclerosis, glaucoma (increased intraocular pressure), hyperthyroidism (excessive production of thyroid hormone), hypertension. With care, they are prescribed under constant supervision if the patient has bipolar disorder, depression, hypertension, liver and kidney diseases, psychosis, Raynaud's syndrome, convulsions.
Side effects
Physical: hypertension or hypotension, Raynaud's syndrome (reduction of blood flow to the extremities), tachycardia, erectile dysfunction, abdominal pain, loss of appetite, nausea, dry mouth, gnashing of teeth, difficulty urinating, reduction or acceleration of the motility of the digestive tract.
Psychological: Mood swings, insomnia, anxiety, irritability, obsessive states. Psychoses when using the drug as prescribed occur very rarely.
Pathological over-activation of the mesolimbic pathway that connects the areas of the ventral lining plays a central role in the formation of drug addiction.
Drug addiction is a serious risk of the non-medical use of Adderall, but it is unlikely to occur as a result of medical use in the prescribed amount. Tolerance is formed quickly with abuse of adderall.
Persons receiving long-term treatment with adderallum and other similar drugs with a sudden discontinuation of administration report a limited withdrawal syndrome, which disappears within 24 hours after their last dose.
Symptoms of withdrawal include anxiety, depressed mood, fatigue, increased appetite, lack of motivation, insomnia, or drowsiness.
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