In March 2011, the FDA published a safety announcement on the risk of magnesium deficiency in anyone taking proton pump inhibitors for more than a year.
And while some people may be protected by taking a daily magnesium supplement, studies suggest that about 25 percent of people who take PPIs are unable to normalize their blood magnesium level with a supplement – they have to stop the drug in order to return their blood magnesium levels to normal.
Long-term reduction in calcium absorption from PPIs also can affect your bone health and increase your risk of osteoporosis.
Magnesium deficiency can contribute to anxiety, restless leg syndrome, insomnia and muscle spasm, life-threatening arrhythmias.
