Posted on Feb 10, 2012, 6 a.m.
Among older people with glucose intolerance, daily resveratrol supplementation improved insulin sensitivity and reduced post-meal spikes in blood sugar.
Previously, a number of studies have suggested positive cardiovascular effects of resveratrol, a powerful antioxidant compound found abundantly in red grapes. As well, other studies have reported anti-cancer, anti-inflammatory, and anti-diabetes potentials, and the compound has been investigated for potential to combat the onset of Alzheimer's disease. Jill P. Crandall, from the Albert Einstein College of Medicine (New York, USA), and colleagues enrolled 10 people, average age 72 years, with age-related glucose intolerance. Each of these subjects were assigned to consume 1 g, 1.5 g, or 2 g of resveratrol per day for four weeks. The researchers found that glucose levels after a meal were significantly reduced as a result of resveratrol, as compared to the baseline for each subject. In addition, resveratrol increased insulin sensitivity. Well-tolerated by the study participants, the study authors conclude that: "At doses between 1 and 2 g/day, resveratrol improves insulin sensitivity and postmeal plasma glucose in subjects with [impaired glucose tolerance].”
Jill P. Crandall, Valerie Oram, Georgeta Trandafirescu, Migdalia Reid, Preeti Kishore, Meredith Hawkins, et al. “Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance.” J Gerontol A Biol Sci Med Sci , January 4, 2012.