Weight Loss And Improved Control In Type 2 Diabetes With The Fasting-Mimicking Diet2 months ago
Posted on Apr 05, 2023, 12 p.m.
Article courtesy of Dr. Joel Kahn, MD, who is a Clinical Professor of Medicine at Wayne State University School of Medicine, one of the world's top cardiologists, a best-selling author, lecturer, and a leading expert in plant-based nutrition and holistic care.
Novel fasting interventions have gained scientific and public attention. Periodic fasting has emerged as a dietary modification promoting beneficial effects on metabolic syndrome and the 5-day Fasting Mimicking Diet (Prolon) has the most scientific support.
The original randomized trial was in healthy volunteers. Now a "proof of concept" study on patients on medication for Type 2 diabetes mellitus (DM) has been published.
Assess whether periodic fasting reduces protein in the urine (albuminuria) in patients with Type 2 DM.
Individuals with type 2 diabetes (n = 40) and increased protein in the urine (albumin-to-creatinine ratio ACR) were randomly assigned to receive a monthly fasting-mimicking diet (FMD) for 5 days every month for 6 months or a Mediterranean diet followed by a 3-month follow-up.
Study Results: F
MD was well tolerated with 71% to 95% of the participants reporting no adverse effects.
After 6 months, FMD led to a reduction of protein in the urine (ACR) in patients with microalbuminuria levels at baseline but not in those with larger amounts called macroalbuminuria.
FMD reduced a research measure of insulin resistance called HOMA-IR.
At follow-up, only HOMA-IR reduction [-1.9 (-3.7, -0.1), P ≤ 0.05]) was sustained.
Improvement of microalbuminuria (ACR) and of markers of insulin resistance suggests the potential beneficial effects of periodic fasting in type 2 diabetes.
Study Comments by Authors:
"After six months, FMD led to significant reductions in body weight of 22 pounds, 1.4% decrease of hemoglobin A1C, and 59% improvement in HOMA-IR, a marker of insulin resistance. At the study's end, antihyperglycemic medication was reduced in 67% of participants in the FMD group compared to baseline. In contrast, 21% of the participants of the Mediterranean Diet group had to increase their antihyperglycemic medication"
"For a diabetes program to effectively impact the daily lives of patients, safety, efficacy, and adherence are equally important," said William Hsu, M.D., Chief Medical Officer at L-Nutra and former Vice President at Harvard's Joslin Diabetes Center. "With these wide-ranging results, we have feasibility data to suggest that Fasting-Mimicking Nutrition Program, combined with personalized nutrition consultation, can be safely and effectively integrated into clinical practice to complement current practice."
About the author: At his core, Dr. Joel Kahn believes that plant-based nutrition is the most powerful source of preventative medicine on the planet. Having practiced traditional cardiology since 1983, it was only after his own commitment to a plant-based vegan diet that Dr. Kahn truly began to delve into the realm of non-traditional diagnostic tools, prevention tactics, and nutrition-based recovery protocols.
As with anything you read on the internet, this article should not be construed as medical advice; please talk to your doctor or primary care provider before changing your wellness routine. This article is not intended to provide a medical diagnosis, recommendation, treatment, or endorsement.
Opinion Disclaimer: The views and opinions expressed in this article are those of the author and do not necessarily reflect the official policy of WHN/A4M. Any content provided by guest authors is of their own opinion and is not intended to malign any religion, ethic group, club, organization, company, individual, or anyone or anything.
Content may be edited for style and length.
References/Sources/Materials provided by: